The importance of technology in embryo culture

Before the embryo transfer, we need to screen and select the embryos with good qualification in terms of pleasant morphology and normal chromosomes in order to increase the success rate.


At Prime Fertility Clinic, we use “Embryo Grading” as a tool to identify which embryos are adequate to be transferred.

During 2 stages of embryonic development, embryo grading will be performed by the embryologist who is a specialist as following:
Cleavage stage (referred to the international criteria of Istanbul Consensus Scoring System)
Blastocyst stage (referred to the international scoring system for evaluating blastocysts proposed by Gardner and Schoolcraft, 1999)

Apart from embryo grading, we also have technology to detect chromosome abnormalities in embryos called Preimplantation Genetic Testing (PGT). This technology is known as Next Generation Sequencing (NGS). NGS gives us high accuracy therefore it is the best method nowadays to detect genetic abnormalities inside embryos thoroughly and select the qualified embryos to be transferred to the uterine cavity.

Some beneficial technologies are used in modern embryo culture e.g., real time embryo monitoring, AI based assessment for embryo selection. To use AI system, we require a huge number of data to be considered with some parameters such as embryo grade and chromosome analysis results. Both real time monitoring method and AI system are only a part of evaluation criteria.

At Prime Fertility Clinic, we provide embryo culture using MINC benchtop incubator for every patient. Embryos of each case are raised individually in micro-drop (closed system). Therefore, we can control pH level, temperature and humidity then create the suitable environment for embryo culture.

One micro-drop is a place for one embryo to grow up. Embryologist can recognize embryos by labelling number individually. This procedure reduces interference against the embryo culture.

Patients of Prime Fertility Clinic will receive their embryo report via telephone or e-mail. Furthermore, they can review their medical records from “Prime Fertility Center” application enable patients to access their personal information anytime.

Satisfied success rate has been shown during the first trimester, 2021. Pregnancy rate is 79% among patients who experienced ICSI treatment at Prime Fertility Clinic.

Reference: Prime Fertility Center Co., Ltd.

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