‘DNA Fragmentation’ How does this happen?

Deoxyribonucleic acid or DNA is a molecule of the organic compound that carries genetic information of an organism.

Resources: Fragmentation DNA | invitra.com

 

If the DNA is damaged or fragmented, it will result in cells’ malfunction. Therefore, when cell division occurs, these irregular traits will be inherited through generations, leading to mutation in next generations.

Sperm is male reproductive cell that fertilizes with ovum and inherits genetic traits to the next generation. As a result, sperm DNA damage could possibly lead to:

• Lower chance of fertilization
• Lower embryo quality
• Lower chance of embryo implantation
• Higher chance of miscarriage

Sperm DNA Fragmentation can occur from various causes such as oxidative stress, aging, smoking, pollution, or some inappropriate lifestyle. These factors could lead to higher oxydants in sperm, resulting in sperm’s malfunction or future mutation. Finally, these factors will damage DNA and lead to DNA fragmentation.

To examine the quality of sperm DNA, we follow the method called “the sperm chromatin dispersion test” (SCD) using the Halosperm G2 kit. After the process of DNA denaturation to extract protein from the head of the sperm, regular sperm DNA will produce the characteristic HALO around the head of the sperm. In contrast, if the sperm is damaged or has DNA fragmentation, the HALO will not or barely appear.

The result of the exam will be the guide to find further suitable treatments such as MACS Sperm or IMSI to help increase the success rate of infertility treatment.

 

Should you be interested in getting fertility consultation, please contact us. | ICSI Bangkok

Prime Fertility Center

Tel. : 062-648-6688 / 062-648-8866 / 02-029-1418–9
Line : http://line.me/ti/p/~@primefertility
Facebook : https://www.facebook.com/primefertilitycenter
E-mail : [email protected]

Working Hours

  • Open: Monday – Wednesday, Friday and Saturday
    Time: 08:00 – 16:00
  • Closed: Thursday, Sunday and Public Holidays

 

Related Posts

10

May
news knowledge-en

Vitamin D deficiency can lead to infertility.

Vitamin D deficiency can lead to infertility. In women, vitamin D is important for female hormones involved in the development and growth of eggs. It has also been found that women with normal vitamin D levels are more likely to be successful in infertility treatment than women with low levels. Vitamin D is also important during pregnancy because it helps develop the fetus. If you are deficient in vitamin D during pregnancy, you are at increased risk of premature birth, gestational diabetes, and gestational hypertension. Therefore, you should get enough […]

10

May
news knowledge-en

Can IUI be done if you are over 35 years old?

Can IUI be done if you are over 35 years old? IUI (Intrauterine Insemination) is the process of taking sperm that has been analyzed in a laboratory to select healthy sperm and injecting it back into the woman’s uterus so that the sperm can swim and mix with the eggs on its own. Who is IUI suitable for? IUI treatment is suitable for couples where the man has a minor sperm problem, the woman has abnormal ovulation, has at least one fallopian tube, and the age should not be over[…]